The prospect of using cell-based interventions to treat neurological conditions raises several important ethical and policy questions. In this target article, we focus on issues related to the unique constellation of traits that characterize CBIs targeted at the central nervous system. In particular, there is at least a theoretical prospect that these cells will alter the recipients' cognition, mood, and behavior—brain functions that are central to our concept of the self. The potential for such changes, although perhaps remote, is cause (...) for concern and careful ethical analysis. Both to enable better informed consent in the future and as an end in itself, we argue that early human trials of CBIs for neurological conditions must monitor subjects for changes in cognition, mood, and behavior; further, we recommend concrete steps for that monitoring. Such steps will help better characterize the potential risks and benefits of CBIs as they are tested and potentially used for treatment. (shrink)

We welcome Ballantyne & Schaefer’s discussion of the issues concerning consent and use of health data for research. In response to their acknowledgement of the need for public debate and discussion, we provide evidence from our own public consultation on this topic.

In lieu of an abstract, here is a brief excerpt of the content:Dharma Bums: The Beat Generation and the Making of Countercultural PilgrimageP. J. JohnstonI believe in the sweetness of Jesus And Buddha— I believe, In St. Francis, Avaloki Tesvara, the Saints Of First Century India A D And Scholars Santidevan And Otherwise Santayanan Everywhere.(Kerouac 1959: 15)Preliminary Polemics“PILGRIM, n. A traveler that is taken seriously.”—Ambrose Bierce, The Devil’s Dictionary 2007: 133As Beat commentator Stephen Prothero describes in his article “On the (...) Holy Road: The Beat Movement as Spiritual Protest” (1991), the Beats and their pilgrimages have most emphatically not been taken seriously. Both critics and scholars have been unkind to members of the Beat generation, and this unkindness has manifested itself in relative neglect of the Beats in all possible aspects of scholarly investigation. But nowhere does this appear more pronounced than in the area of Beat religion. Though some recent scholarship has been picking up from this earlier neglect and it is now [End Page 165] possible to find serious biographies of most of the major Beat writers and some belated attention to the movement as a literary phenomenon, the only book-length treatment of Beat Buddhism I was able to locate (Tonkinson 1995) hardly qualifies as a scholarly work and was published not by an academic press but as a special feature of the Buddhist magazine Tricycle. Prothero hypothesizes that this is because of the movement’s reputation as rebellious and antinomian—in its heyday the movement was characterized in identical unsavory terms by publications representing interests as diverse as Life and Playboy, with the latter describing the Beats as “nihilists” and the former claiming that the Beats were at war with “Mom, Dad, Politics, Marriage, the Savings Bank, Organized Religion, Literary Elegance, Law, the Ivy League Suit and Higher Education, to say nothing of the Automatic Dishwasher, the Cellophane-wrapped Soda Cracker, the Split-Level House and the clean, or peace-provoking H-bomb” (Prothero 1991: 206). Norman Podhoretz of Partisan Review went further still, claiming that the Beats were “hostile to civilization” and that the movement as a whole amounted to “a revolt of the spiritually underprivileged and crippled of soul” and “an affirmation of death” (ibid., 206). One couldn’t ask for a more passionate disavowal of the Beats or a more thorough polemic that the movement was profoundly antireligious.This could not contrast more with the Beats’ representation of their movement and its aims, with Jack Kerouac going so far as to reinterpret the crucial term “Beat” (a term for someone down and out originally borrowed from criminal street jive) as a noun derived from the adjective “beatific,” a specifically religious term familiar from such phrases as “the beatific vision” (ibid., 206–207). Several of the representative Beat writers were practicing Buddhists, influencing the entire movement to such an extent that Buddhist ideas and imagery suffused Beat literature as a whole. Ginsberg and Kerouac especially emphasized the positive and constructive elements of their spiritual vision, arguing that literature such as On the Road and Howl should be understood as religious affirmations of what is good and holy rather than as purely critical undertakings: “For the crucifix I speak out, for the Star of Israel I speak out, for the divinest man who ever lived who was German (Bach) I speak out, for sweet Mohammed I speak out, for Buddha I speak out, for Lao-tse and Chuang-tse I speak out” (ibid., 206–207). Or, as Allen Ginsberg put it less lyrically (and rather more bluntly): “Howl is an ‘Affirmation’ by individual experience of God, sex, drugs, and absurdity... the poems are religious and I meant them to be” (ibid., 207).But for the most part, Beat asseverations in no way diminished scholarly wariness about the Beat movement and its spirituality—as Prothero concludes, “the tendency among literary scholars is to see these [religious] concerns as tangential rather than constitutive” while “historians of American religion who have explored beat spirituality have tended to focus almost exclusively on the beats’ engagement with Zen and then to dismiss that engagement as haphazard” (ibid., 207).It is my contention that the mainstream scholarly neglect of Beat spirituality is in some part... (shrink)

MATTER AND LIGHT The New Physics By LOUIS DE BROGLIE. Originally published in 1937. TRANSLATORS NOTE: THE Author has in certain places modified the original French text for the English translation, for the sake of greater cohesion, and has also revised some passages, in order to bring them into accord with the results of later research. Occasional Translators Notes are shown in square brackets. The chapter on The Undulatory Aspects of the Electron has the special historical interest of having been (...) delivered as a Lecture on the occasion of the Authors receipt of the Nobel Award, while that on Wave Mechanics and its Interpretations was given as an Address at the Glasgow meeting of the British Association in 1928. I am indebted to Dr. J. E. Turner, of the University of Liver pool, for assistance with the translation and the proofs, and to Dr. C. Strachan, of the same University, I am indebted for valuable assistance in dealing with the equations and the more technical passages, as well as for reading the proofs. W. H. J. PREFACE: THE amiable insistence of my friend Andr George has induced me to collect in the present Volume a number of Studies on con temporary Physics written from both the general and the more metaphysical point of view. Each of these Studies forms an inde pendent whole, and can be read by itself. A slight degree of repeti tion which the reader is asked to overlook has been the inevi table result for on more than one occasion I have been compelled to duplicate a summary of the great fundamental stages of con temporary Physics, such as the classification of simple substances, the investigation of the photo-electric effect and the origin of the Theory of Light Quanta and of Wave Mechanics the subjects are somewhat technical, and I cannot well assume that they are common knowledge. But though the same subject is outlined in several of these Studies, I have tried to take up a different point of view in each, and have endeavoured to throw light on different aspects of the essential problems of Quantum Physics in order to facilitate a grasp of their importance. On comparing the different chapters the reader will observe that, while overlapping, they also complement one another and he will feel the fascination and greatness inherent in the vast structure of modern Physics. And while admiring the vast number and the extreme delicacy of experimental facts which laboratory physicists have succeeded in revealing, and the strange and brilliant concepts devised by theorists to explain them, he will appreciate to what a degree the methods and ideas of physicists have grown in subtlety during recent years, and how great has been the progress from the somewhat ingenuous Realism and the over-simplified Mechanics of earlier thinkers. The more deeply we descend into the minutest structures of Matter, the more clearly we see that the concepts evolved by the mind in the course of everyday experience especially those of Time and Space must fail us in an endeavour to describe the new worlds which we are entering. One feels tempted to say that the outlines of our concepts must undergo a progressive blurring, in order that they may retain some semblance of relevance to the realities of the subatomic scales. Time and Space, in other words, are too loose a dress for the elementary entities individuality becomes attenuated in the mysterious pro cesses of interaction, and even Determinism, the darling of an older generation of physicists, is forced to yield... (shrink)

This paper describes the introduction of Liebig's ideas on agricultural chemistry into the Netherlands. The aversion to Liebig held by the Utrecht professor G. J. Mulder hindered the direct influence that might have been borne by Liebig's own writings; the introduction was made principally by means of Dutch translations of the text-books of the Scottish agricultural chemist J. F. W. Johnston, who generally followed Liebig's ideas.

This volume assesses the ethical, quantitative, and qualitative questions posed by the current financing of biomedical research.

This book is a specialized monograph on the development of the mathematical and computational metatheory of reductive logic and proof-search, areas of logic that are becoming important in computer science. A systematic foundational text on these emerging topics, it includes proof-theoretic, semantic/model-theoretic and algorithmic aspects. The scope ranges from the conceptual background to reductive logic, through its mathematical metatheory, to its modern applications in the computational sciences. Suitable for researchers and graduate students in mathematical, computational and philosophical logic, and in (...) theoretical computer science and artificial intelligence, this is the latest in the prestigous world-renowned Oxford Logic Guides, which contains Michael Dummet's Elements of intuitionism, Dov M. Gabbay, Mark A. Reynolds, and Marcelo Finger's Temporal Logic Mathematical Foundations and Computational Aspects, J. M. Dunn and G. Hardegree's Algebraic Methods in Philosophical Logic, H. Rott's Change, Choice and Inference: A Study of Belief Revision and Nonmonotonic Reasoning, and P. T. Johnstone's Sketches of an Elephant: A Topos Theory Compendium: Volumes 1 and 2. (shrink)

The contributions to this special collection concern issues and problems discussed in or related to the work of Wesley C. Salmon. Salmon has long been noted for his important work in the philosophy of science, which has included research on the interpretation of probability, the nature of explanation, the character of reasoning, the justification of induction, the structure of space/time and the paradoxes of Zeno, to mention only some of the most prominent. During a time of increasing preoccupation with historical (...) and sociological approaches to under standing science (which characterize scientific developments as though they could be adequately analysed from the perspective of political movements, even mistaking the phenomena of conversion for the rational appraisal of scientific theories), Salmon has remained stead fastly devoted to isolating and justifying those normative standards distinguishing science from non-science - especially through the vindi cation of general principles of scientific procedure and the validation of specific examples of scientific theories - without which science itself cannot be (even remotely) adequately understood. In this respect, Salmon exemplifies and strengthens a splendid tradi tion whose most remarkable representatives include Hans Reichenbach, Rudolf Carnap and Carl G. Hempel, all of whom exerted a profound influence upon his own development. (shrink)

This collection of essays is the definitive version of a widely discussed debate over the origins of the New Theory of Reference. In new articles, written especially for this volume, Quentin Smith and Scott Soames, the original participants in the debate, elaborate their positions on who was responsible for the ideas that Saul Kripke presented in his Naming and Necessity. They are joined by John Burgess, who weighs in on the side of Soames, while Smith adds a further dimension in (...) discussing the contributions of philosophers such as Follesdal, Geach, Hintikka, and Plantinga. Also included are lengthy excerpts from Follesdal's 1961 Harvard dissertation and a careful examination by Sten Lindstrom of the respective contributions of Kripke and Stig Kanger to the development of modal semantics. The collection will be essential reading for anyone acquainted with these influential ideas. (shrink)

This additional volume offers a revised edition of Lingua , Erasmus’ work on language, its possibilities and the dangers in its use, ending in a praise of the Word of God. Since it deals with the moral implications of language, Erasmus placed it in Ordo IV that comprises works on moral issues.